Ontology highlight
ABSTRACT:
SUBMITTER: Kumar N
PROVIDER: S-EPMC6659620 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Kumar Niraj N Cramer Gwendolyn M GM Dahaj Seyed Alireza Zamani SAZ Sundaram Bala B Celli Jonathan P JP Kulkarni Rahul V RV
Scientific reports 20190726 1
Phenotypic heterogeneity in cancer cells is widely observed and is often linked to drug resistance. In several cases, such heterogeneity in drug sensitivity of tumors is driven by stochastic and reversible acquisition of a drug tolerant phenotype by individual cells even in an isogenic population. Accumulating evidence further suggests that cell-fate transitions such as the epithelial to mesenchymal transition (EMT) are associated with drug resistance. In this study, we analyze stochastic models ...[more]