Ontology highlight
ABSTRACT:
SUBMITTER: Sarkar MK
PROVIDER: S-EPMC4616153 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nature communications 20151019
The transcriptional imbalance due to the difference in the number of X chromosomes between male and female mammals is remedied through X-chromosome inactivation, the epigenetic transcriptional silencing of one of the two X chromosomes in females. The X-linked Xist long non-coding RNA functions as an X inactivation master regulator; Xist is selectively upregulated from the prospective inactive X chromosome and is required in cis for X inactivation. Here we discover an Xist antisense long non-codi ...[more]