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Therapeutic potential of chemokine signal inhibition for metastatic breast cancer.


ABSTRACT: Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/macrophages to the site of metastasis, and discuss whether inhibition of these chemokine signals can represent a new therapeutic strategy for metastatic breast cancer.

SUBMITTER: Kitamura T 

PROVIDER: S-EPMC4617477 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Therapeutic potential of chemokine signal inhibition for metastatic breast cancer.

Kitamura Takanori T   Pollard Jeffrey W JW  

Pharmacological research 20150811


Metastatic breast cancer is incurable by current therapies including chemotherapy and immunotherapy. Accumulating evidence indicates that tumor-infiltrating macrophages promote establishment of the lethal metastatic foci and contribute to therapeutic resistance. Recent studies suggest that the accumulation of these macrophages is regulated by a chemokine network established in the tumor microenvironment. In this perspective paper, we elaborate on the chemokine signals that can attract monocytes/  ...[more]

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