Ontology highlight
ABSTRACT:
SUBMITTER: De Cola A
PROVIDER: S-EPMC6062508 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Cell death & disease 20180726 8
Mir-205 plays an important role in epithelial biogenesis and in mammary gland development but its role in cancer still remains controversial depending on the specific cellular context and target genes. We have previously reported that miR-205-5p is upregulated in breast cancer stem cells targeting ERBB pathway and leading to targeted therapy resistance. Here we show that miR-205-5p regulates tumorigenic properties of breast cancer cells, as well as epithelial to mesenchymal transition. Silencing ...[more]