Ontology highlight
ABSTRACT:
SUBMITTER: Lee SH
PROVIDER: S-EPMC4618081 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Lee Suk Hyung SH Johnson Daniel T DT Luong Richard R Yu Eun Jeong EJ Cunha Gerald R GR Nusse Roel R Sun Zijie Z
Stem cells (Dayton, Ohio) 20150729 11
The precise role of Wnt/β-catenin signaling during prostatic development and tumorigenesis is unclear. Axin2 is a direct transcriptional target of β-catenin. Recent studies have shown that Axin2-expressing cells have stem/progenitor cell properties in a variety of mouse tissues. Here, we genetically labeled Axin2-expressing cells at various time points and tracked their cellular behavior at different developmental and mature stages. We found that prostatic Axin2-expressing cells mainly express l ...[more]