Ontology highlight
ABSTRACT:
SUBMITTER: Pierce MR
PROVIDER: S-EPMC4618169 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Journal of neuroscience research 20150914 12
It has been shown that vitamin C (VC) is transported at synaptic boutons, but how this occurs has not been elucidated. This study investigates the role of the sodium-dependent vitamin C transporter-2 (SVCT2) in transporting VC at the cortical nerve terminal. Immunostaining of cultured mouse superior cervical ganglion cells showed the SVCT2 to be expressed in presynaptic boutons, colocalizing with the vesicular monoamine transporter-2 and the norepinephrine transporter. Immunoblotting of enriched ...[more]