Ontology highlight
ABSTRACT:
SUBMITTER: Venkatesan S
PROVIDER: S-EPMC4618328 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Venkatesan SanthoshKannan S Saha Kusumika K Sohail Azmat A Sandtner Walter W Freissmuth Michael M Ecker Gerhard F GF Sitte Harald H HH Stockner Thomas T
PLoS computational biology 20151020 10
Glutamate homeostasis in the brain is maintained by glutamate transporter mediated accumulation. Impaired transport is associated with several neurological disorders, including stroke and amyotrophic lateral sclerosis. Crystal structures of the homolog transporter GltPh from Pyrococcus horikoshii revealed large structural changes. Substrate uptake at the atomic level and the mechanism of ion gradient conversion into directional transport remained enigmatic. We observed in repeated simulations th ...[more]