Ontology highlight
ABSTRACT:
SUBMITTER: Aravantinou-Fatorou K
PROVIDER: S-EPMC4618597 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Aravantinou-Fatorou Katerina K Ortega Felipe F Chroni-Tzartou Dafni D Antoniou Nasia N Poulopoulou Cornelia C Politis Panagiotis K PK Berninger Benedikt B Matsas Rebecca R Thomaidou Dimitra D
Stem cell reports 20150828 3
Recent studies demonstrate that astroglia from non-neurogenic brain regions can be reprogrammed into functional neurons through forced expression of neurogenic factors. Here we explored the effect of CEND1 and NEUROG2 on reprogramming of mouse cortical astrocytes and embryonic fibroblasts. Forced expression of CEND1, NEUROG2, or both resulted in acquisition of induced neuronal cells expressing subtype-specific markers, while long-term live-cell imaging highlighted the existence of two different ...[more]