Ontology highlight
ABSTRACT:
SUBMITTER: Takayama Y
PROVIDER: S-EPMC5347899 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Takayama Yuzo Y Wakabayashi Tamami T Kushige Hiroko H Saito Yutaka Y Shibuya Yoichiro Y Shibata Shinsuke S Akamatsu Wado W Okano Hideyuki H Kida Yasuyuki S YS
FEBS letters 20170209 4
In this study, we propose a novel method for inducing neuronal cells by briefly exposing them to small-molecule cocktails in a step-by-step manner. Global gene expression analysis with immunohistochemical staining and calcium flux assays reveal the generation of neurons from mouse embryonic fibroblasts. In addition, time-lapse imaging of neural precursor-specific enhancer expression and global gene expression analyses show that the neurons are generated by passing through a neural crest-like pre ...[more]