Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC4618654 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Xu Xiaoti X Wilschut Karlijn J KJ Kouklis Gayle G Tian Hua H Hesse Robert R Garland Catharine C Sbitany Hani H Hansen Scott S Seth Rahul R Knott P Daniel PD Hoffman William Y WY Pomerantz Jason H JH
Stem cell reports 20150901 3
Identification of human satellite cells that fulfill muscle stem cell criteria is an unmet need in regenerative medicine. This hurdle limits understanding how closely muscle stem cell properties are conserved among mice and humans and hampers translational efforts in muscle regeneration. Here, we report that PAX7 satellite cells exist at a consistent frequency of 2-4 cells/mm of fiber in muscles of the human trunk, limbs, and head. Xenotransplantation into mice of 50-70 fiber-associated, or 1,00 ...[more]