Ontology highlight
ABSTRACT:
SUBMITTER: Liu R
PROVIDER: S-EPMC4620056 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Liu Runhua R Yi Bin B Wei Shi S Yang Wei-Hsiung WH Hart Karen M KM Chauhan Priyanka P Zhang Wei W Mao Xicheng X Liu Xiuping X Liu Chang-Gong CG Wang Lizhong L
Cancer research 20150223 8
The tumor-suppressive activity of FOXP3 has been observed in tumor initiation, but the underlying mechanism still remains largely unknown. Here, we identified a FOXP3-microRNA-146 (miR-146)-NF-κB axis in vitro and in vivo in prostate cancer cells. We observed that FOXP3 dramatically induced the expression of miR-146a/b, which contributed to transcriptional inhibition of IRAK1 and TRAF6, in prostate cancer cell lines. Tissue-specific deletion of Foxp3 in mouse prostate caused a significant reduct ...[more]