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Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis.


ABSTRACT: Rapid and efficient methods for the determination of cured tuberculosis (TB) are lacking. A total of 85 differentially expressed serum proteins were identified by iTRAQ labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) analysis (fold change >1.50 or <0.60, P?

SUBMITTER: Wang C 

PROVIDER: S-EPMC4620482 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis.

Wang Chong C   Wei Li-Liang LL   Shi Li-Ying LY   Pan Zhi-Fen ZF   Yu Xiao-Mei XM   Li Tian-Yu TY   Liu Chang-Ming CM   Ping Ze-Peng ZP   Jiang Ting-Ting TT   Chen Zhong-Liang ZL   Mao Lian-Gen LG   Li Zhong-Jie ZJ   Li Ji-Cheng JC  

Scientific reports 20151026


Rapid and efficient methods for the determination of cured tuberculosis (TB) are lacking. A total of 85 differentially expressed serum proteins were identified by iTRAQ labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) analysis (fold change >1.50 or <0.60, P < 0.05). We validated albumin (ALB), Rho GDP-dissociation inhibitor 2 (ARHGDIB), complement 3 (C3), ficolin-2 (FCN2), and apolipoprotein (a) (LPA) using the enzyme-linked immunosorbent assay (  ...[more]

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