Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis.
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ABSTRACT:
SUBMITTER: Wang C
PROVIDER: S-EPMC4620482 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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Screening and identification of five serum proteins as novel potential biomarkers for cured pulmonary tuberculosis.
Wang Chong C Wei Li-Liang LL Shi Li-Ying LY Pan Zhi-Fen ZF Yu Xiao-Mei XM Li Tian-Yu TY Liu Chang-Ming CM Ping Ze-Peng ZP Jiang Ting-Ting TT Chen Zhong-Liang ZL Mao Lian-Gen LG Li Zhong-Jie ZJ Li Ji-Cheng JC
Scientific reports 20151026
Rapid and efficient methods for the determination of cured tuberculosis (TB) are lacking. A total of 85 differentially expressed serum proteins were identified by iTRAQ labeling coupled with two-dimensional liquid chromatography-tandem mass spectrometry (2D LC-MS/MS) analysis (fold change >1.50 or <0.60, P < 0.05). We validated albumin (ALB), Rho GDP-dissociation inhibitor 2 (ARHGDIB), complement 3 (C3), ficolin-2 (FCN2), and apolipoprotein (a) (LPA) using the enzyme-linked immunosorbent assay ( ...[more]
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