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Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial.


ABSTRACT:

SUBMITTER: Leder BZ 

PROVIDER: S-EPMC4620731 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial.

Leder Benjamin Z BZ   Tsai Joy N JN   Uihlein Alexander V AV   Wallace Paul M PM   Lee Hang H   Neer Robert M RM   Burnett-Bowie Sherri-Ann M SA  

Lancet (London, England) 20150702 9999


<h4>Background</h4>Unlike most chronic diseases, osteoporosis treatments are generally limited to a single drug at a fixed dose and frequency. Nonetheless, no approved therapy is able to restore skeletal integrity in most osteoporotic patients and the long-term use of osteoporosis drugs is controversial. Thus, many patients are treated with the sequential use of two or more therapies. The DATA study showed that combined teriparatide and denosumab increased bone mineral density more than either d  ...[more]

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