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The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples.

ABSTRACT: Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5-PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely that the YPEL5-PPP1CB fusion is a good drug target in CLL or a suitable target to monitor disease.

SUBMITTER: Vandepoele K

PROVIDER: S-EPMC4621498 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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The YPEL5-PPP1CB fusion transcript is detected in different hematological malignancies and in normal samples.

Vandepoele Karl K Philippé Jan J Denys Barbara B

Leukemia research reports 20150806 2

Chronic lymphocytic leukemia (CLL) is the most frequent leukemia in Western adults. It was suggested that transcripts from a reciprocal trans-splicing event between YPEL5 and PPP1CB were present exclusively in CLL patients (more than 90%). Here we show that the YPEL5-PPP1CB fusion is not specific for CLL but is also detected in other hematological malignancies such as chronic myeloid leukemia, monoclonal B cell lymphocytosis or acute leukemia and also in normal samples. As such, it is unlikely t ...[more]

PMID: 26605151

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