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Metabolic status and resistin in chronic schizophrenia over a 2-year period with continuous atypical antipsychotics.


ABSTRACT: BACKGROUND:Common adverse effects of atypical antipsychotic treatments for schizophrenia are weight gain and lipid metabolism abnormality. We aimed to identify the signs of metabolic problems with continuous atypical antipsychotic treatment for schizophrenia over a 2-year period. METHODS:The participants were 68 schizophrenic patients (29 males, 39 females; ages 53.4 ± 13.5 years old). Changes in carbohydrate metabolism and changes in physical characteristics were studied over a 2-year period. In addition, functional single nucleotide polymorphisms in the transcriptional regulatory region of the resistin gene were examined. RESULTS:We found no changes in the mental state of the participants over a 2-year period. Patients did show a significant decrease in total cholesterol and hemoglobin A1c levels, although physical changes such as body mass index and abdominal girth, were not observed. The amount of resistin may not be associated with mental states and physical parameters. CONCLUSIONS:We could not find physical factors related to metabolic changes of antipsychotics in this 2-year study. However, several psychological factors, such as health-related thoughts and behaviors, should be studied in the future.

SUBMITTER: Kawabe K 

PROVIDER: S-EPMC4622120 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature

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Metabolic status and resistin in chronic schizophrenia over a 2-year period with continuous atypical antipsychotics.

Kawabe Kentaro K   Ochi Shinichiro S   Yoshino Yuta Y   Mori Yoko Y   Onuma Hiroshi H   Osawa Haruhiko H   Hosoda Yoshiki Y   Ueno Shu-Ichi S  

Therapeutic advances in psychopharmacology 20151001 5


<h4>Background</h4>Common adverse effects of atypical antipsychotic treatments for schizophrenia are weight gain and lipid metabolism abnormality. We aimed to identify the signs of metabolic problems with continuous atypical antipsychotic treatment for schizophrenia over a 2-year period.<h4>Methods</h4>The participants were 68 schizophrenic patients (29 males, 39 females; ages 53.4 ± 13.5 years old). Changes in carbohydrate metabolism and changes in physical characteristics were studied over a 2  ...[more]

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