Towards a gene expression biomarker set for human biological age.
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ABSTRACT:
SUBMITTER: Holly AC
PROVIDER: S-EPMC4623317 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Towards a gene expression biomarker set for human biological age.
Holly Alice C AC Melzer David D Pilling Luke C LC Henley William W Hernandez Dena G DG Singleton Andrew B AB Bandinelli Stefania S Guralnik Jack M JM Ferrucci Luigi L Harries Lorna W LW
Aging cell 20130130 2
We have previously described a statistical model capable of distinguishing young (age <65 years) from old (age ≥75 years) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional measures consistent with a younger biological age. Those with 'younger' gene expression patterns demonstrated higher muscle strength and serum albumin, and lowe ...[more]
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