Ontology highlight
ABSTRACT:
SUBMITTER: Rubinstein R
PROVIDER: S-EPMC4624033 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Rubinstein Rotem R Thu Chan Aye CA Goodman Kerry Marie KM Wolcott Holly Noelle HN Bahna Fabiana F Mannepalli Seetha S Ahlsen Goran G Chevee Maxime M Halim Adnan A Clausen Henrik H Maniatis Tom T Shapiro Lawrence L Honig Barry B
Cell 20151017 3
Self-avoidance, a process preventing interactions of axons and dendrites from the same neuron during development, is mediated in vertebrates through the stochastic single-neuron expression of clustered protocadherin protein isoforms. Extracellular cadherin (EC) domains mediate isoform-specific homophilic binding between cells, conferring cell recognition through a poorly understood mechanism. Here, we report crystal structures for the EC1-EC3 domain regions from four protocadherin isoforms repre ...[more]