Ontology highlight
ABSTRACT:
SUBMITTER: Rubinstein R
PROVIDER: S-EPMC5582985 | biostudies-literature | 2017 Sep
REPOSITORIES: biostudies-literature
Rubinstein Rotem R Goodman Kerry Marie KM Maniatis Tom T Shapiro Lawrence L Honig Barry B
Seminars in cell & developmental biology 20170722
Clustered protocadherins mediate neuronal self-recognition and non-self discrimination-neuronal "barcoding"-which underpin neuronal self-avoidance in vertebrate neurons. Recent structural, biophysical, computational, and cell-based studies on protocadherin structure and function have led to a compelling molecular model for the barcoding mechanism. Protocadherin isoforms assemble into promiscuous cis-dimeric recognition units and mediate cell-cell recognition through homophilic trans-interactions ...[more]