Ontology highlight
ABSTRACT:
SUBMITTER: Pardi N
PROVIDER: S-EPMC4624045 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Pardi Norbert N Tuyishime Steven S Muramatsu Hiromi H Kariko Katalin K Mui Barbara L BL Tam Ying K YK Madden Thomas D TD Hope Michael J MJ Weissman Drew D
Journal of controlled release : official journal of the Controlled Release Society 20150808
In recent years, in vitro transcribed messenger RNA (mRNA) has emerged as a potential therapeutic platform. To fulfill its promise, effective delivery of mRNA to specific cell types and tissues needs to be achieved. Lipid nanoparticles (LNPs) are efficient carriers for short-interfering RNAs and have entered clinical trials. However, little is known about the potential of LNPs to deliver mRNA. Here, we generated mRNA-LNPs by incorporating HPLC purified, 1-methylpseudouridine-containing mRNA comp ...[more]