Ontology highlight
ABSTRACT:
SUBMITTER: Kauffman KJ
PROVIDER: S-EPMC5267554 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Kauffman Kevin J KJ Mir Faryal F FF Jhunjhunwala Siddharth S Kaczmarek James C JC Hurtado Juan E JE Yang Jung H JH Webber Matthew J MJ Kowalski Piotr S PS Heartlein Michael W MW DeRosa Frank F Anderson Daniel G DG
Biomaterials 20160925
mRNA has broad potential for treating diseases requiring protein expression. However, mRNA can also induce an immune response with associated toxicity. Replacement of uridine bases with pseudouridine has been postulated to modulate both mRNA immunogenicity and potency. Here, we explore the immune response and activity of lipid nanoparticle-formulated unmodified and pseudouridine-modified mRNAs administered systemically in vivo. Pseudouridine modification to mRNA had no significant effect on lipi ...[more]