Ontology highlight
ABSTRACT:
SUBMITTER: Rodgers J
PROVIDER: S-EPMC4624684 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
PLoS neglected tropical diseases 20151027 10
Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both clinical cases and experimental mouse infections it has been demonstrated that predisposition to CNS invasion is associated with a type 1 systemic inflammatory response. Using the Trypanosoma brucei brucei GVR35 experimental infection model, we demonstrate that systemic delivery of the counter-inflammatory cytokine IL-10 lowers plasma IFN-γ ...[more]