Ontology highlight
ABSTRACT:
SUBMITTER: Vickery ON
PROVIDER: S-EPMC4906246 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Vickery Owen N ON Machtens Jan-Philipp JP Tamburrino Giulia G Seeliger Daniel D Zachariae Ulrich U
Structure (London, England : 1993) 20160519 6
G-protein-coupled receptors (GPCRs) form the largest superfamily of membrane proteins and one-third of all drug targets in humans. A number of recent studies have reported evidence for substantial voltage regulation of GPCRs. However, the structural basis of GPCR voltage sensing has remained enigmatic. Here, we present atomistic simulations on the δ-opioid and M2 muscarinic receptors, which suggest a structural and mechanistic explanation for the observed voltage-induced functional effects. The ...[more]