Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Lluch S
PROVIDER: S-EPMC4625605 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Nature genetics 20150817 10
The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results sup ...[more]