Ontology highlight
ABSTRACT:
SUBMITTER: Boya R
PROVIDER: S-EPMC5737614 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Nucleic acids research 20171101 19
Genome organization in 3D nuclear-space is important for regulation of gene expression. However, the alterations of chromatin architecture that impinge on the B cell-fate choice of multi-potent progenitors are still unclear. By integrating in situ Hi-C analyses with epigenetic landscapes and genome-wide expression profiles, we tracked the changes in genome architecture as the cells transit from a progenitor to a committed state. We identified the genomic loci that undergo developmental switch be ...[more]