Ontology highlight
ABSTRACT:
SUBMITTER: Krupovic M
PROVIDER: S-EPMC4625639 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Krupovic Mart M Cvirkaite-Krupovic Virginija V Prangishvili David D Koonin Eugene V EV
Biology direct 20151029
Many proteins of viruses infecting hyperthermophilic Crenarchaeota have no detectable homologs in current databases, hampering our understanding of viral evolution. We used sensitive database search methods and structural modeling to show that a nucleocapsid protein (TP1) of Thermoproteus tenax virus 1 (TTV1) is a derivative of the Cas4 nuclease, a component of the CRISPR-Cas adaptive immunity system that is encoded also by several archaeal viruses. In TTV1, the Cas4 gene was split into two, wit ...[more]