Ontology highlight
ABSTRACT:
SUBMITTER: Tack J
PROVIDER: S-EPMC4625753 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
United European gastroenterology journal 20151001 5
<h4>Background</h4>Treatment options for patients with opioid-induced constipation (OIC) and inadequate response to laxatives (LIR) are few.<h4>Objective</h4>Assess the efficacy and safety of orally administered naloxegol in patients with prospectively confirmed OIC and LIR.<h4>Methods</h4>We analyzed pooled data from two identical randomized, double-blind, placebo-controlled, Phase 3 trials of naloxegol in patients with non-cancer pain, OIC and LIR in which naloxegol (12.5 mg, n = 240; 25 mg, n ...[more]