Ontology highlight
ABSTRACT:
SUBMITTER: Al-Huniti N
PROVIDER: S-EPMC4961079 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20160720 7
Naloxegol is a polyethylene glycol derivative of naloxone approved in the US as a once-daily oral treatment for opioid-induced constipation (OIC) in adults with chronic noncancer pain. Population exposure-response models were constructed based on data from two phase III studies comprising 1,331 adults with noncancer pain and OIC. In order to characterize the protocol-defined naloxegol responder rate, the number of daily spontaneous bowel movements (SBMs) was characterized by a longitudinal ordin ...[more]