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Bone turnover in long-term survivors of childhood acute lymphoblastic leukemia.


ABSTRACT: We investigated the effects of demographic, lifestyle (self-reported smoking status and physical activity levels), cancer-related treatment factors (radiation and chemotherapy), and diet (calcium and vitamin D intake) on bone turnover and the relationship of bone turnover to lumbar spine bone mineral density (BMD) Z-scores (LS-BMD Z-scores) determined by quantitative computed tomography (QCT) in 418 ?5-year survivors of childhood acute lymphoblastic leukemia (ALL).Bone turnover was assessed by biomarkers including serum bone-specific alkaline phosphatase (BALP), osteocalcin (OC), and urinary N-telopeptide of type I collagen indexed to creatinine (NTX/Cr). The 215 males ranged in age from 9 to 36 years (median age 17 years).Age and tanner score were inversely associated with all biomarkers (BALP, OC, NTX/Cr) (P?

SUBMITTER: Watsky MA 

PROVIDER: S-EPMC4625912 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Bone turnover in long-term survivors of childhood acute lymphoblastic leukemia.

Watsky Mitchell A MA   Carbone Laura D LD   An Qi Q   Cheng Cheng C   Lovorn Elizabeth A EA   Hudson Melissa M MM   Pui Ching-Hon CH   Kaste Sue C SC  

Pediatric blood & cancer 20140320 8


<h4>Background</h4>We investigated the effects of demographic, lifestyle (self-reported smoking status and physical activity levels), cancer-related treatment factors (radiation and chemotherapy), and diet (calcium and vitamin D intake) on bone turnover and the relationship of bone turnover to lumbar spine bone mineral density (BMD) Z-scores (LS-BMD Z-scores) determined by quantitative computed tomography (QCT) in 418 ≥5-year survivors of childhood acute lymphoblastic leukemia (ALL).<h4>Procedur  ...[more]

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