Ontology highlight
ABSTRACT:
SUBMITTER: Van de Mark D
PROVIDER: S-EPMC4626064 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20150902 21
Mouse double-minute 1 (Mdm1) was originally identified as a gene amplified in transformed mouse cells and more recently as being highly up-regulated during differentiation of multiciliated epithelial cells, a specialized cell type having hundreds of centrioles and motile cilia. Here we show that the MDM1 protein localizes to centrioles of dividing cells and differentiating multiciliated cells. 3D-SIM microscopy showed that MDM1 is closely associated with the centriole barrel, likely residing in ...[more]