Gene expression profile analysis of ventilator-associated pneumonia.

ABSTRACT: Based on the gene expression profile of patients with ventilator-associated pneumonia (VAP) and patients not affected by the disease, the present study aimed to enhance the current understanding of VAP development using bioinformatics methods. The expression profile GSE30385 was downloaded from the Gene Expression Omnibus database. The Linear Models for Microarray Data package in R language was used to screen and identify differentially expressed genes (DEGs), which were grouped as up‑ and down‑regulated genes. The up‑ and downregulated genes were functionally enriched using the Database for Annotation, Visualization and Integrated Discovery system and then annotated according to TRANSFAC, Tumor Suppressor Gene and Tumor Associated Gene databases. Subsequently, the protein‑protein interact

SUBMITTER: Xu X 

PROVIDER: S-EPMC4626132 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature