Ontology highlight
ABSTRACT:
SUBMITTER: Lin CW
PROVIDER: S-EPMC4626804 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Lin Chih-Wen CW Chen Yaw-Sen YS Lin Chih-Che CC Chen Yun-Ju YJ Lo Gin-Ho GH Lee Po-Huang PH Kuo Po-Lin PL Dai Chia-Yen CY Huang Jee-Fu JF Chung Wang-Long WL Yu Ming-Lung ML
Scientific reports 20151030
The deregulation of autophagy is involved in liver regeneration. Here, we investigated the role of autophagy in the regulation of liver regeneration after partial hepatectomy (PHx) and the development of pharmacological interventions for improved liver regeneration after PHx. We show that autophagy was activated in the early stages of liver regeneration following 70% PHx in vivo. Moreover, amiodarone was associated with a significant enhancement of autophagy, liver growth, and hepatocyte prolife ...[more]