Ontology highlight
ABSTRACT: Conclusion
Our data suggest that Fak is involved in the process of liver regeneration, and inhibition of FAK may be a promising strategy to accelerate liver regeneration in recipients after liver transplantation.
SUBMITTER: Shang N
PROVIDER: S-EPMC5039626 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20160928
Understanding the molecular mechanisms of liver regeneration is essential to improve the survival rate of patients after surgical resection of large amounts of liver tissue. Focal adhesion kinase (FAK) regulates different cellular functions, including cell survival, proliferation and cell migration. The role of FAK in liver regeneration remains unknown. In this study, we found that Fak is activated and induced during liver regeneration after two-thirds partial hepatectomy (PHx). We used mice wit ...[more]