Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion.
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ABSTRACT:
SUBMITTER: Pulito C
PROVIDER: S-EPMC4627240 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
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Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion.
Pulito Claudio C Mori Federica F Sacconi Andrea A Casadei Luca L Ferraiuolo Maria M Valerio Maria Cristina MC Santoro Raffaela R Goeman Frauke F Maidecchi Anna A Mattoli Luisa L Manetti Cesare C Di Agostino Silvia S Muti Paola P Blandino Giovanni G Strano Sabrina S
Oncotarget 20150701 20
Malignant pleural mesothelioma is a poorly treated neoplasia arising from the pleural mesothelial lining. Here we document that the leaf extract of Cynara scolymus exerts broad antitumoral effects both in vitro and in vivo on mesothelioma cell lines. We found that Cynara scolymus treatment affects strongly cell growth, migration and tumor engraftment of mesothelioma cell lines. Strikingly, dietary feeding with Cynara scolymus leaf extract reduces the growth of mesothelioma xenografted tumors sim ...[more]
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