Ontology highlight
ABSTRACT:
SUBMITTER: Dyshlovoy SA
PROVIDER: S-EPMC4627311 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Dyshlovoy Sergey A SA Hauschild Jessica J Amann Kerstin K Tabakmakher Ksenia M KM Venz Simone S Walther Reinhard R Guzii Alla G AG Makarieva Tatiana N TN Shubina Larisa K LK Fedorov Sergey N SN Stonik Valentin A VA Bokemeyer Carsten C Balabanov Stefan S Honecker Friedemann F von Amsberg Gunhild G
Oncotarget 20150701 19
Monanchocidin A (MonA) is a novel alkaloid recently isolated from the marine sponge Monanchora pulchra. The compound reveals cytotoxic activity in genitourinary cancers including cisplatin-sensitive and -resistant germ cell tumor (GCT) cell lines, hormone-sensitive and castration-resistant prostate carcinoma cell lines and different bladder carcinoma cell lines. In contrast, non-malignant cells were significantly less sensitive. MonA is highly synergistic with cisplatin in GCT cells. Induction o ...[more]