Ontology highlight
ABSTRACT:
SUBMITTER: Guo W
PROVIDER: S-EPMC4627719 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Guo Wentian W Ni Yang Y Ji Yuan Y
Statistics in biosciences 20150630 2
In many oncology clinical trials it is necessary to insert new candidate doses when the prespecified doses are poorly elicited. Formal statistical designs with dose insertion are lacking. We propose a dose insertion design for phase I/II clinical trials in oncology based on both efficacy and toxicity outcomes. We also implement Bayesian model selection during the course of the trial so that better models can be adaptively chosen to achieve more accurate inference. The new design, TEAMS, achieves ...[more]