Mixed tau and TDP-43 pathology in a patient with unclassifiable primary progressive aphasia.
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ABSTRACT:
SUBMITTER: Flanagan EP
PROVIDER: S-EPMC4628904 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Publications
Mixed tau and TDP-43 pathology in a patient with unclassifiable primary progressive aphasia.
Flanagan Eoin P EP Duffy Joseph R JR Whitwell Jennifer L JL Vemuri Prashanthi P Dickson Dennis W DW Josephs Keith A KA
Neurocase 20150501 1
Classifying primary progressive aphasia (PPA) into variants that may predict the underlying pathology is important. However, some PPA patients cannot be classified. A 78-year-old woman had unclassifiable PPA characterized by anomia, dysarthria, and apraxia of speech without agrammatism. Magnetic resonance imaging revealed left mesial temporal atrophy and 18-flourodeoxy-glucose positron emission tomography showed left anterior temporal and posterior frontal (premotor) hypometabolism. Autopsy reve ...[more]
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