Ontology highlight
ABSTRACT:
SUBMITTER: Yano M
PROVIDER: S-EPMC4629142 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Yano Masamichi M Akazawa Hiroshi H Oka Toru T Yabumoto Chizuru C Kudo-Sakamoto Yoko Y Kamo Takehiro T Shimizu Yu Y Yagi Hiroki H Naito Atsuhiko T AT Lee Jong-Kook JK Suzuki Jun-ichi J Sakata Yasushi Y Komuro Issei I
Scientific reports 20151102
Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step in the salvage pathway for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and thereby regulates the deacetylase activity of sirtuins. Here we show accommodative regulation of myocardial NAD(+) by monocyte-derived extracellular Nampt (eNampt), which is essential for hemodynamic compensation to pressure overload. Although intracellular Nampt (iNampt) expression was decreased in pressure-overloaded hearts, myo ...[more]