Ontology highlight
ABSTRACT:
SUBMITTER: Kornev AP
PROVIDER: S-EPMC4630092 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Kornev Alexandr P AP Taylor Susan S SS
Trends in biochemical sciences 20151021 11
Protein kinases have very dynamic structures and their functionality strongly depends on their dynamic state. Active kinases reveal a dynamic pattern with residues clustering into semirigid communities that move in μs-ms timescale. Previously detected hydrophobic spines serve as connectors between communities. Communities do not follow the traditional subdomain structure of the kinase core or its secondary structure elements. Instead they are organized around main functional units. Integration o ...[more]