A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice.
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ABSTRACT:
SUBMITTER: Machado AS
PROVIDER: S-EPMC4630674 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
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A quantitative framework for whole-body coordination reveals specific deficits in freely walking ataxic mice.
Machado Ana S AS Darmohray Dana M DM Fayad João J Marques Hugo G HG Carey Megan R MR
eLife 20151003
The coordination of movement across the body is a fundamental, yet poorly understood aspect of motor control. Mutant mice with cerebellar circuit defects exhibit characteristic impairments in locomotor coordination; however, the fundamental features of this gait ataxia have not been effectively isolated. Here we describe a novel system (LocoMouse) for analyzing limb, head, and tail kinematics of freely walking mice. Analysis of visibly ataxic Purkinje cell degeneration (pcd) mice reveals that wh ...[more]
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