Neurodevelopment. Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling.
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ABSTRACT:
SUBMITTER: Joo W
PROVIDER: S-EPMC4631524 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Neurodevelopment. Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling.
Joo William W Hippenmeyer Simon S Luo Liqun L
Science (New York, N.Y.) 20141001 6209
Neurotrophins regulate diverse aspects of neuronal development and plasticity, but their precise in vivo functions during neural circuit assembly in the central brain remain unclear. We show that the neurotrophin receptor tropomyosin-related kinase C (TrkC) is required for dendritic growth and branching of mouse cerebellar Purkinje cells. Sparse TrkC knockout reduced dendrite complexity, but global Purkinje cell knockout had no effect. Removal of the TrkC ligand neurotrophin-3 (NT-3) from cerebe ...[more]
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