Ontology highlight
ABSTRACT:
SUBMITTER: Cordonier EL
PROVIDER: S-EPMC4631641 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Cordonier Elizabeth L EL Adjam Riem R Teixeira Daniel Camara DC Onur Simone S Zbasnik Richard R Read Paul E PE Döring Frank F Schlegel Vicki L VL Zempleni Janos J
The Journal of nutritional biochemistry 20150726 11
Holocarboxylase synthetase (HLCS) is the sole protein-biotin ligase in the human proteome. HLCS has key regulatory functions in intermediary metabolism, including fatty acid metabolism, and in gene repression through epigenetic mechanisms. The objective of this study was to identify food-borne inhibitors of HLCS that alter HLCS-dependent pathways in metabolism and gene regulation. When libraries of extracts from natural products and chemically pure compounds were screened for HLCS inhibitor acti ...[more]