Ontology highlight
ABSTRACT:
SUBMITTER: Lu YF
PROVIDER: S-EPMC4631997 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Scientific reports 20151104
Polymorphisms near the interferon lambda 3 (IFNL3) gene strongly predict clearance of hepatitis C virus (HCV) infection. We analyzed a variant (rs4803217 G/T) located within the IFNL3 mRNA 3' untranslated region (UTR); the G allele (protective allele) is associated with elevated therapeutic HCV clearance. We show that the IFNL3 3' UTR represses mRNA translation and the rs4803217 allele modulates the extent of translational regulation. We analyzed the structures of IFNL3 variant mRNAs at nucleoti ...[more]