Ontology highlight
ABSTRACT:
SUBMITTER: Gaide O
PROVIDER: S-EPMC4632197 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Gaide Olivier O Emerson Ryan O RO Jiang Xiaodong X Gulati Nicholas N Nizza Suzanne S Desmarais Cindy C Robins Harlan H Krueger James G JG Clark Rachael A RA Kupper Thomas S TS
Nature medicine 20150511 6
Central memory T (TCM) cells in lymph nodes (LNs) and resident memory T (TRM) cells in peripheral tissues have distinct roles in protective immunity. Both are generated after primary infections, but their clonal origins have been unclear. To address this question, we immunized mice through the skin with a protein antigen, a chemical hapten, or a non-replicating poxvirus. We then analyzed antigen-activated T cells from different tissues using high-throughput sequencing (HTS) of the gene encoding ...[more]