Ontology highlight
ABSTRACT:
SUBMITTER: Bemark M
PROVIDER: S-EPMC5025876 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Bemark Mats M Hazanov Helena H Strömberg Anneli A Komban Rathan R Holmqvist Joel J Köster Sofia S Mattsson Johan J Sikora Per P Mehr Ramit R Lycke Nils Y NY
Nature communications 20160906
Understanding how memory B cells are induced and relate to long-lived plasma cells is important for vaccine development. Immunity to oral vaccines has been considered short-lived because of a poor ability to develop IgA B-cell memory. Here we demonstrate that long-lived mucosal IgA memory is readily achieved by oral but not systemic immunization in mouse models with NP hapten conjugated with cholera toxin and transfer of B1-8(high)/GFP(+) NP-specific B cells. Unexpectedly, memory B cells are poo ...[more]