DNA-methylation in C1R is a prognostic biomarker for acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Bozic T
PROVIDER: S-EPMC4632269 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
DNA-methylation in C1R is a prognostic biomarker for acute myeloid leukemia.
Božić Tanja T Lin Qiong Q Frobel Joana J Wilop Stefan S Hoffmann Melanie M Müller-Tidow Carsten C Brümmendorf Tim H TH Jost Edgar E Wagner Wolfgang W
Clinical epigenetics 20151104
<h4>Background</h4>Epigenetic aberrations play a central role in the pathophysiology of acute myeloid leukemia (AML). It has been shown that molecular signatures based on DNA-methylation (DNAm) patterns can be used for classification of the disease. In this study, we followed the hypothesis that DNAm at a single CpG site might support risk stratification in AML.<h4>Findings</h4>Using DNAm profiles of 194 patients from The Cancer Genome Atlas (TCGA), we identified a CpG site in complement compone ...[more]
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