Ontology highlight
ABSTRACT:
SUBMITTER: Sng J
PROVIDER: S-EPMC7257641 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Sng Joel J Ayoglu Burcu B Chen Jeff W JW Schickel Jean-Nicolas JN Ferre Elise M N EMN Glauzy Salomé S Romberg Neil N Hoenig Manfred M Cunningham-Rundles Charlotte C Utz Paul J PJ Lionakis Michail S MS Meffre Eric E
Science immunology 20190401 34
Autoimmune regulator (AIRE) mutations result in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome characterized by defective central T cell tolerance and the production of many autoantibodies targeting tissue-specific antigens and cytokines. By studying CD3- and AIRE-deficient patients, we found that lack of either T cells or AIRE function resulted in the peripheral accumulation of autoreactive mature naïve B cells. Proteomic arrays and Biacore affinity measurement ...[more]