Ontology highlight
ABSTRACT:
SUBMITTER: Spinner CA
PROVIDER: S-EPMC4633680 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Spinner Camille A CA Uttenweiler-Joseph Sandrine S Metais Arnaud A Stella Alexandre A Burlet-Schiltz Odile O Moog-Lutz Christel C Lamsoul Isabelle I Lutz Pierre G PG
Scientific reports 20151105
Conventional dendritic cells (cDCs) comprise distinct populations with specialized immune functions that are mediators of innate and adaptive immune responses. Transcriptomic and proteomic approaches have been used so far to identify transcripts and proteins that are differentially expressed in these subsets to understand the respective functions of cDCs subsets. Here, we showed that the Cullin 5-RING E3 ubiquitin ligase (E3) ASB2α, by driving degradation of filamin A (FLNa) and filamin B (FLNb) ...[more]