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Total Synthesis of (-)-Secu'amamine A Exploiting Type II Anion Relay Chemistry.

ABSTRACT: A total synthesis of (-)-secu'amamine A has been achieved exploiting Type II Anion Relay Chemistry (ARC) to provide the full linear carbon and nitrogen skeleton in a single flask with the requisite stereochemistry and functionality. A mechanistic rationale is also proposed to account for the stereochemical outcome of the key aldol reaction leading to the advanced aza tricyclic core.

SUBMITTER: Han H

PROVIDER: S-EPMC4633699 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Total Synthesis of (-)-Mandelalide A Exploiting Anion Relay Chemistry (ARC): Identification of a Type II ARC/CuCN Cross-Coupling Protocol.

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