Ontology highlight
ABSTRACT:
SUBMITTER: Farrell M
PROVIDER: S-EPMC4726982 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20151120 1
The design, synthesis, and validation of new highly effective bifunctional linchpins for type II anion relay chemistry (ARC) has been achieved. The mechanistically novel negative-charge migration that comprises the Brook rearrangement is now initiated by a stabilized tetrahedral intermediate, which is generated by nucleophilic addition to a Weinreb amide, rather than by a simple oxyanion that is generated from an epoxide. As a result, the linchpin preserves the carbonyl functionality in the ARC ...[more]