Ontology highlight
ABSTRACT:
SUBMITTER: Taniguchi R
PROVIDER: S-EPMC4633820 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Taniguchi Reiya R Kato Hideaki E HE Font Josep J Deshpande Chandrika N CN Wada Miki M Ito Koichi K Ishitani Ryuichiro R Jormakka Mika M Nureki Osamu O
Nature communications 20151013
In vertebrates, the iron exporter ferroportin releases Fe(2+) from cells into plasma, thereby maintaining iron homeostasis. The transport activity of ferroportin is suppressed by the peptide hormone hepcidin, which exhibits upregulated expression in chronic inflammation, causing iron-restrictive anaemia. However, due to the lack of structural information about ferroportin, the mechanisms of its iron transport and hepcidin-mediated regulation remain largely elusive. Here we report the crystal str ...[more]